The dinox group provides consultancy services (dinox consultancy bv) and operates an investigational site in Berlin (dinox GmbH). Dinox GmbH conducts trials with the specific requirements of studies in females, and is equipped to deal with the logistical challenge of large numbers of subjects requiring cycle-dependent transvaginal ultrasonography (TVUS) with frequent blood sampling, e.g. for the assessment of follicular growth. In cooperation with neighbouring CRO’s, providing overnight stays in Berlin, also PK/PD studies can be performed.
dinox bv was founded in 1993 in Nijmegen, the Netherlands and relocated to Groningen, the Netherlands in 2004. dinox GmbH was founded in 1999 as a second investigational site in Berlin, Germany. Both companies merged in 2018 and continued as dinox GmbH.
Throughout the years, the experts at dinox have provided consultancy in many clinical development programs, study design development, selection of pharmacodynamic assessments, interpretation of data from TVUS and hormone results, recruitment strategies and all aspects concerning the female population in clinical studies. Dinox consultancy bv, was founded in 2013 providing these supplementary consultancy services.
Dinox has been involved in the development of many hormonal contraceptive preparations and profertility drugs during the last 25 years. This comprises combined and
progesterone-only oral preparations, vaginal rings, patches, implants and IUDs, treatment for dysmenorrhea, endometriosis and subfertility and hormone replacement therapy. Furthermore, dinox has investigated a potential interaction of several drugs with standard combined oral contraceptives. A lot of the tested IMPs are meanwhile brand medicinal products.